FIS4-Cell-W Biological Cell Wavefront Sensor

In life science research, traditional cell staining observation can interfere with cell viability and fails to enable long-term dynamic tracking. The FIS4-Cell-W biological cell wavefront sensor, developed by a research team led by Professor Yang Yongying from Zhejiang University, leverages years of accumulation in four-wave shearing interference technology to introduce a novel observation approach that is label-free, non-invasive, and high-fidelity.

This sensor is suitable for cancer cell diagnosis, stem cell culture, drug development research, and blood morphology observation. It can clearly capture cell morphology and dynamic changes without staining or labeling. By capturing the inherent phase information of cells for imaging, it achieves 'what you see is what you get' without the need for staining or labeling. Utilizing a common-path interference system, it exhibits excellent adaptability to environmental vibrations and temperature and humidity fluctuations. There is no need to build a special vibration isolation platform, as it can be directly integrated into conventional biological microscope systems, achieving stable and high-contrast cell phase imaging, significantly reducing the threshold for laboratory deployment.

The accompanying fully self-developed analysis software provides complete process support for researchers, from imaging to quantitative analysis: a user-friendly interactive interface that can present the three-dimensional morphology and phase distribution of cells in real time, and a dynamic acquisition function that supports long-term tracking of cell morphological changes; the software has built-in automatic calculation modules for key parameters such as phase, thickness, and refractive index, supports custom observation areas and data export, and can quickly obtain traceable quantitative results.

As a domestically developed biomedical optical device, the FIS4-Cell-W biological cell wavefront sensor offers a truly viable new path for label-free cell imaging with its solid performance and localized services. It provides a more substantial foothold for China's intelligent manufacturing in the field of high-end optical detection and adds a reliable option to global biomedical research.