Observe and measure the three-dimensional morphology and dynamic changes of living cells without any staining or labeling process
The four-wave Lateral shear Interferometry (FIS4) technique also has potential applications in labeling free 3D living cell detection, due to its non-contact, non-destructive measurement characteristics and high spatial resolution. Here are some potential applications of the FIS4 technology for labeling free 3D living cell detection:
1. Cell morphology studies: FIS4 technology can be used to observe and measure the three-dimensional morphology and dynamic changes of living cells without any staining or labeling process. This is particularly important for studying the morphological changes of cells in different physiological states.
2. Cell growth and division monitoring: By monitoring the growth and division process of cells in real time, FIS4 technology can provide important information about cell cycle and proliferation, which is very valuable for cell biology and drug development research fields.
3. Imaging the internal structure of cells: FIS4 technology allows researchers to observe the dynamics of the microstructures inside cells, such as the nucleus and organelles, without interfering with cell activity.
4. Cell-environment interaction: Cells undergo morphological changes when they interact with their external environment, and the FIS4 technology can be used to study these changes to understand how cells respond to external stimuli.
5. Tissue engineering and regenerative medicine: In tissue engineering, monitoring the growth and tissue formation of cells in 3D scaffolds is critical to building functional tissues. The FIS4 technology is able to provide this information without destroying the sample.
6. Drug screening and toxicity testing: In the drug development process, live cell assays without labeling can be used to evaluate the effects and toxicity of drugs, and FIS4 technology can provide rapid and detailed data on cell morphological changes.
7. Cancer research: Cancer cells differ from normal cells in morphology and mechanical properties, and FIS4 technology can help researchers study these differences without changing the natural state of the cells.
Measurement advantage
Complete measurement with a single frame
◆ Living cells do not need to be stained
◆ Long-term observation of 3D morphology of living cells
◆ Support cell counting, segmentation and weighing
High resolution
◆ Up to 512×512 phase sampling points
◆ High dynamic range
◆ Nanoscale sensitivity
Easy to adjust integration
◆ Small and compact
◆ Support parallel and convergent beams
◆ Super vibration resistance
Measurement example
▎Unlabeled 3D living cell detection optical path
▎Labeling free 3D living cell assay - Paramecia
Measurement demonstration
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